Ane Doki is a lot different from the most ''I have my first love, but how can it work out?!'' mangas.

Ane Doki is about a boy named Kouta who used to live with his father who left him alone in a weird way, to work outside the city. Earlier he met with a high school girl who at first just wanted his Ice cream.
His father left him and the High School girl, Natsuki, pops up, wanting to do a favor back. And so she decides by herself to be his maid and will be living in his house.
Natsuki always do things on her way and that gives Kouta pervy thoughts. But Natsuki stays doing things on her way and even goes to his school just to bring him a bento.
What goes wrong, ofcourse. The boys at his school can't forget about her and are getting jealous at Kouta for being so close with her. But there is one person Kouta likes at school, Sakurai, the most popular girl on school.
After he saved Sakurai once from 3 guys, she falls in love with him and can't stand Natsuki, who also tries to get Sakurai and Kouta closer.
Things are getting more complicated when Natsuki's younger sister found them and also decided to live with them until Natsuki wants to go home.
Later on Kouta doesn't think about Sakurai in the same way as she thinks of him, but he started to fall for Natsuki.