If you read the original manga and thought the technobabble was confusing, this manga is quite a bit worse in that respect. Where I could somewhat keep up with the plot of the first volume, this volume takes the technobabble to the extreme, with a very large portion of the story being the protagonist endlessly spouting information that only the most tech-savvy people would understand.

As for the characters, the vast majority of the story is our hero (Matoko from the first volume fused with the puppeteer calling itself/herself "Matoko Aramaki") jumping into puppet bodies stashed all over the world in order to fight crime like a true vigilante. As one of the readers in a Q&A in one of the volumes said, this makes it somewhat difficult to form a connection with the character, as it is not always clear which body is Aramaki, and even when it is, her look is always changing because of this.

Aside from the endless confusion of the technobabble, the hard to follow political plots, and the difficulty to form an attatchment to the main character, there are some interesting spiritual ideas brought forth in the last few chapters (or part of chapters, since the chapters seem to be split up into parts).

Overall, I cannot see myself rereading this, but if you are a hardcore fan of Ghost in the Shell and are very knowledgeable about computer applications and viruses, you may very well enjoy Man-Machine Interface.