Your average, cute, office-romance 4-koma. Yea, OK, like 60% of the humor is derived from boob jokes, but for all that, I don't really find it offensive or crass.

The general premise: Takeda Kouta ('newbie' or 'Takeda-san) starts working at XOX Corporation, under the direct supervision of the titular boss, Takizawa Kyouko ('sempai' or Takizawa-san). Takizawa is an extremely well-endowed foodie who is somewhat unaware of the effect her assets seem to have on your everyday bloke. She's not entirely clueless about the matter -- that would be pretty obnoxious -- but most of the series' comedy derives from the tension between the obvious distraction of her boobs pose to Takeda, who is otherwise a model employee and overall polite, nice guy.

It should be stated that the relationship between Takeda and Takizawa is cute and largely-wholesome; for all that this is a manga about a big-breasted boss, there's not much lewd about it. Especially as the series progresses, I would argue it's much more about Takeda and Takizawa's budding relationship (as co-workers, friends, even more...?) and that the boobs occupy more of a comedic relief role (and an obvious reminder that there is some attraction between the two) and less of an ecchi/fanservice role.

If you're looking for some light, easily-digested fluff that outside the high school romance box, give Bijin Onna Joushi Takizawa-san a shot.